In its prime, Cahokia was a prosperous city with a population similar to London’s. But this sprawling Native American metropolis from the Mississippian culture vanished long before Europeans arrived in North America. What happened? This Indigenous city’s enigmatic rise and fall has inspired countless theories and has long captivated the imaginations of archaeologists. And now, cutting-edge scientific research offers a glimmer of hope in unraveling the mystery of Cahokia's disappearance.