And sidebars or overflow arrows? Which could be hidden but work by scrolling. But I have the feeling these are avoided, even when they could help reduce space used.
If you are referring the @Thalatta's last mock, then the dead space would always be less then current ModernGUI layout (10 slots vs current 12) but it's a bit closer to screen center which might look worse as said above. Your other points I acknowledged them in the last comment, so agreed but you always have to make compromises, goal is to make the best ones.
We're back to first exchange : too much clutter, too much space used. The second option is just slightly better enough to make it interesting.