Ardashir I: progenitor of the Sasanian dynasty, reinvigorated the idea of a Persian empire as a successor of Achaemenid Persia. May have an aura or tech about adding vigor to the civ, for example increases building construction speed. Maybe enables Immortals (Zhayedan).
Shapur I: tolerance for religions other than the prevailing Zoroastrianism such as Manichaeism or Judaism may present an interesting opportunity. Especially Manichaeism as a potential world religion in a what-if scenario perhaps? May give increased influence over the map such as increased territory bonus. Maybe also enable some Armenian unit via his conquest of Armenia and governorship of his son and successor.
Shapur II: counter to Shapur I, something about religious doctrine, such as stronger priests or temples? Also enables or strengthens war elephants. See the references in this article for reference:
https://www.iranicaonline.org/articles/elephant-ii-sasanian-army/
Khosrow I: tax reform giving increased resources per resource obtained from sources, and bonuses to noble Aswaran cavalry. See:
https://www.iranicaonline.org/articles/kosrow-1-parent/kosrow-i-ii-reforms/
Khosrow II: not sure, he appears to be partly responsible to bring the empire down? Why not something to represent quick expansion and loss, such as globally reducing building capture, or to make it a bonus, reduce own building capture and while reducing capturing enemy building even more.