Our mods are also sandboxed, and shouldn't be able to get access to random files, or get access to system memory. So at most they would be able to crash the game.
But it all depends on how good the sandboxing is. It's easy to have a bug that suddenly does expose parts of the filesystem or memory. That said, SpiderMonkey is made to execute scripts from unknown origin (scripts from webpages), so the sandboxing on their side should be done quite well.