Thanks @Waker for the tip (right click on the shortcut / Properties / Compatibility / high DPI settings), it also solved my problem.
I believe I was facing the same issue.
Config:
Windows 10 with NVidia driver
fresh install of 0 A.D. Release 28: Boiorix
QHD screen
Symptom: blurry text and NVidia driver overlay, so not just a font issue. This persisted even after fixing
xres=2560
yres=1440
in the config.cfg file.
Only the Compatibility / high DPI settings change solved the issue.