How big is the difference? The mouse in game cursor points to the upper left with an arrow. but what it is actually pointing to is on the bottom left. Basically, it's pointing to the upper left corner but it's actually on the bottom left. Do you start the game in fullscreen mode? Yes I start the game in full screen mode. Is the cursor offset from the start of the game? Yes, it starts off misaligned. What happens if you switch to windowed mode (Alt+Enter)? OH WOW! Switching into windowed mode actually fixes the mouse cursor misalignment. However, I dislike playing in windowed mode due to accidentally clicking on things outside of the game.